Additionally sulfated xylomannan sulfates from Scinaia hatei and their antiviral activities

SAYANI RAY; C. A. PUJOL; E B DAMONTE; BIMALENDU RAY

CARBOHYDRATE POLYMERS

ELSEVIER SCI LTD

Lugar: Amsterdam; Año: 2015 vol. 131 p. 315 - 321

0144-8617

tHerpes simplex viruses (HSVs) display affinity for cell-surface heparan sulfate proteoglycans withbiological relevance in virus entry. This study demonstrates the potential of chemically engineered sul-fated xylomannans from Scinaia hatei as antiHSV drug candidate. Particularly, a dimethylformamide−SO3/pyridine based procedure has been employed for the generation of anionic polysaccharides. Thisone-step procedure has the power of providing a spectrum of xylomannans with varying molecularmasses (<12?74 kDa), sulfate content (1?50%) and glycosyl composition. Especially, the sulfated xylo-mannans S1F1 and S2F1 possessed altered activity against HSV-1 and HSV-2 compared to the parentalcompound (F1) and that too in the absence of drug-induced cytotoxicity. Regarding methodological facet,the directive decoration of hydroxyl functionality with sulfate group plus changes in the molecular massand sugar composition during isolation by the used reagent opens a door for the production of newmolecular entity with altered biological activity from other natural sources.