IQUIBICEN 23947
INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CIENCIAS EXACTAS Y NATURALES
Unidad Ejecutora - UE
artículos
Título:
Microwave-Assisted Synthesis of Pyrrolo[2,1-b]thiazoles Linked to a Carbohydrate Moiety
Autor/es:
JOSÉ SEBASTIÁN BARRADAS; MARÍA INÉS ERREA; CLAUDIA SOLEDAD SEPÚLVEDA; ELSA BEATRIZ DAMONTE; NORMA BEATRIZ D'ACCORSO
Revista:
JOURNAL OF HETEROCYCLIC CHEMISTRY
Editorial:
WILEY-BLACKWELL PUBLISHING, INC
Referencias:
Lugar: Londres; Año: 2014 vol. 51 p. 96 - 100
ISSN:
0022-152X
Resumen:
Herein, we describe the synthesis of pyrrolo[2,1-b]thiazoles substituted on C-2 or C-5 with a protected
carbohydrate moiety. The new fused bicyclic heterocycles were obtained via thiazole intermediates, and
the N-alkylation step was assisted by microwave irradiation. The new products were completely characterized
by physical and spectroscopic techniques. The cytotoxicity and antiviral activity against Junín virus
of the methylated derivates was also evaluated.
carbohydrate moiety. The new fused bicyclic heterocycles were obtained via thiazole intermediates, and
the N-alkylation step was assisted by microwave irradiation. The new products were completely characterized
by physical and spectroscopic techniques. The cytotoxicity and antiviral activity against Junín virus
of the methylated derivates was also evaluated.
carbohydrate moiety. The new fused bicyclic heterocycles were obtained via thiazole intermediates, and
the N-alkylation step was assisted by microwave irradiation. The new products were completely characterized
by physical and spectroscopic techniques. The cytotoxicity and antiviral activity against Junín virus
of the methylated derivates was also evaluated.
carbohydrate moiety. The new fused bicyclic heterocycles were obtained via thiazole intermediates, and
the N-alkylation step was assisted by microwave irradiation. The new products were completely characterized
by physical and spectroscopic techniques. The cytotoxicity and antiviral activity against Junín virus
of the methylated derivates was also evaluated.
carbohydrate moiety. The new fused bicyclic heterocycles were obtained via thiazole intermediates, and
the N-alkylation step was assisted by microwave irradiation. The new products were completely characterized
by physical and spectroscopic techniques. The cytotoxicity and antiviral activity against Junín virus
of the methylated derivates was also evaluated.
carbohydrate moiety. The new fused bicyclic heterocycles were obtained via thiazole intermediates, and
the N-alkylation step was assisted by microwave irradiation. The new products were completely characterized
by physical and spectroscopic techniques. The cytotoxicity and antiviral activity against Junín virus
of the methylated derivates was also evaluated.
carbohydrate moiety. The new fused bicyclic heterocycles were obtained via thiazole intermediates, and
the N-alkylation step was assisted by microwave irradiation. The new products were completely characterized
by physical and spectroscopic techniques. The cytotoxicity and antiviral activity against Junín virus
of the methylated derivates was also evaluated.
carbohydrate moiety. The new fused bicyclic heterocycles were obtained via thiazole intermediates, and
the N-alkylation step was assisted by microwave irradiation. The new products were completely characterized
by physical and spectroscopic techniques. The cytotoxicity and antiviral activity against Junín virus
of the methylated derivates was also evaluated.
b]thiazoles substituted on C-2 or C-5 with a protected
carbohydrate moiety. The new fused bicyclic heterocycles were obtained via thiazole intermediates, and
the N-alkylation step was assisted by microwave irradiation. The new products were completely characterized
by physical and spectroscopic techniques. The cytotoxicity and antiviral activity against Junín virus
of the methylated derivates was also evaluated.
