IQUIBICEN 23947
INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CIENCIAS EXACTAS Y NATURALES
Unidad Ejecutora - UE
artículos
Título:
Altered expression of cytokines in mice infected intranasally with two syncytial variants of Herpes simplex virus type 1
Autor/es:
ARTUSO MC, LINERO FN, GAZZANIGA S, SCOLARO L, PUJOL C, WAINSTOK R, CARLUCCI MJ
Revista:
MICROBIAL PATHOGENESIS
Editorial:
ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD
Referencias:
Lugar: Amsterdam; Año: 2014 p. 1 - 5
ISSN:
0882-4010
Resumen:
Immune evasion strategies are important for the onset and the maintenance of viral infections. Many
viruses have evolved mechanisms to counteract or suppress the host immune response. We have previously
characterized two syncytial (syn) variants of Herpes simplex 1 (HSV-1) strain F, syn14-1 and
syn17-2, obtained by selective pressure with a natural carrageenan. These variants showed a differential
pathology in vaginal and respiratory mucosa infection in comparison with parental strain. In this paper,
we evaluated the modulation of immune response in respiratory mucosa by these HSV-1 variants. We
observed altered levels of Tumor Necrosis Factor-a and Interleukin-6 in lungs of animals infected with
the syn14-1 and syn17-2 variants compared with the parental strain. Also, we detected differences in the
recruitment of immune cells to the lung in syn variants infected mice. Both variants exhibit one point
mutation in the sequence of the gene of glycoprotein D detected in the ectodomain of syn14-1 and the
cytoplasmic tail of syn17-2. Results obtained in the present study contribute to the characterization of
HSV-1 syn variants and the participation of the cellular inflammatory response in viral pathogenesis.
the syn14-1 and syn17-2 variants compared with the parental strain. Also, we detected differences in the
recruitment of immune cells to the lung in syn variants infected mice. Both variants exhibit one point
mutation in the sequence of the gene of glycoprotein D detected in the ectodomain of syn14-1 and the
cytoplasmic tail of syn17-2. Results obtained in the present study contribute to the characterization of
HSV-1 syn variants and the participation of the cellular inflammatory response in viral pathogenesis.
the syn14-1 and syn17-2 variants compared with the parental strain. Also, we detected differences in the
recruitment of immune cells to the lung in syn variants infected mice. Both variants exhibit one point
mutation in the sequence of the gene of glycoprotein D detected in the ectodomain of syn14-1 and the
cytoplasmic tail of syn17-2. Results obtained in the present study contribute to the characterization of
HSV-1 syn variants and the participation of the cellular inflammatory response in viral pathogenesis.
a and Interleukin-6 in lungs of animals infected with
the syn14-1 and syn17-2 variants compared with the parental strain. Also, we detected differences in the
recruitment of immune cells to the lung in syn variants infected mice. Both variants exhibit one point
mutation in the sequence of the gene of glycoprotein D detected in the ectodomain of syn14-1 and the
cytoplasmic tail of syn17-2. Results obtained in the present study contribute to the characterization of
HSV-1 syn variants and the participation of the cellular inflammatory response in viral pathogenesis.flammatory response in viral pathogenesis.
2014 Published by Elsevier Ltd.2014 Published by Elsevier Ltd.
