CONICET | Buscador de Institutos y Recursos Humanos

ABSTRACT Objective: To analyze the antimicrobials consumption in a private hospital of third level of care of Cordoba, Argentina and its evolution between the months of August to November of 2008-2011. Methods: was performed a descriptive cross-sectional study including all patients admitted to hospital with antimicrobial treatment, without excluding pathologies. Data were obtained from the Software Galeno ® of the institution. The consumption was expressed in daily defined doses (DDD) per 100 stays-days. Results: The average consumption was 52.46. Implementing the program for rational use of antimicrobial (P-RUA) in 2009 led to a reduction in consumption that year, with no increase in nosocomial infections. However, since 2010 the DDD/100 stay-day values returned to previous years. Cephalosporins and penicillins accounted for between 68 and 73 % of total consumption of antimicrobials between 2008 and 2011. The first generation cephalosporins contributed to 80% of the consumption of this family in 2008, with an increase in time, while the consumption of the second and third generation decreased. Cefazolin was the drug most commonly consumed only surpassed in 2011 by Ampicillin+sulbactam. The DDD/100 stay-days of ?controlled use antimicrobials? increased between 2008 and 2011. Conclusions: The situation is favorable when comparing the consumption with other institutions of similar size in the country or abroad. Newest antimicrobial agents commonly used in other centers are not yet used in this hospital. Thus, these therapeutic alternatives are available for the future. This study will enable us to discuss any new strategies to strengthen the compliance of the P-RUA that already exists.