Praziquantel-chitosan microparticles prepared through a conventional and modified ionotropic gelation process.Development of a microparticulate oral dosage form.

ORLANDI S.; REAL, D.; LEONARDI, D.; SALOMON, C.J.

Munster

Congreso; 13th International Conference on Chitin and Chitosan; 2015

PRAZIQUANTEL-CHITOSAN MICROPARTICLES PREPARED THROUGH A CONVENTIONAL AND MODIFIED IONOTROPIC GELATION PROCESS. DEVELOPMENT OF A MICROPARTICULATE ORAL DOSAGE FORMINTRODUCTION: Praziquantel (PZQ) is an antihelmintic drug widely used to treat schistosomiasis and other trematode and cestode neglected infections. PZQ has very low water solubility and high permeability. Then, the rate limiting process of absorption is the drug dissolution step, a key factor in formulation development. Microencapsulation into hydrophilic polymers, such as Chitosan, is one of the useful tools to increase the aqueous solubility and dissolution rate of lipophilic drugs including PZQ. OBJETIVES: The aim of the present work was the development of a novel solid dosage form containing PZQ microparticles. Such microparticles were formulated through the ionic interaction of chitosan (CH) with sodium lauryl sulphate (SLS). CONCLUSIONS: It was found that PZQ/CH/SLS microparticle made by spray drying technique is a convenient approach to remarkable increase the PZQ dissolution rate. Particularly the method 2 was able to increased PZQ dissolution rate more than three times as compared to the non-treated drug. Spray drying was shown to be a simple and adequate technique for drug particle size reduction up to 1 mm. X-ray analysis showed a reduction in the crystaline estructure of PZQ, probably due to the process of encapsulation. The results obtained have suggested that the polymeric carrier yielded from the ionic interaction between CH and SLS may be used as a promising alternative for the delivery of PZQ.