Experimental design model applied to the preformulation of Praziquantel solutions.

ORLANDI S.; PRIOTTI J.; LEONARDI D.; SALOMON C.J.

Rosario

Congreso; II Reunión Internacional de Ciencias Farmacéuticas (RICIFA); 2012

Praziquantel (PZQ) is an effective drug prescribed for the treatment of infections caused by endoparasites such as schistosomas, staves and taenias. PZQ shows a low solubility (about 0,4 mg/mL) and therefore an erratic bioavailability. One of the methodologies widely used to increase the solubility of poorly water soluble drugs is its incorporation into cosolvent systems. Propylene glycol (PPG), ethanol, glycerin and polyethylene glycol (PEG) 400 are solvents commonly used in this type of systems due to their biocompatibility. Often, the cosolvents systems are combined with surfactants in order to further increase the solubility of hydrophobic molecules. Therefore, the aim of this work was the development of PZQ liquid systems based on cosolvents, surfactants and its combination mixtures through the application of experimental design models.