Characterization and optimization of albendazole loaded ternary polymeric microparticles

GARCÍA, A.; LEONARDI, D.; LAMAS, M.C.

Antalaya

Simposio; 18th International Symposium on Microencapsulation; 2011

Albendazole (ALB), methyl (5-[propylthio]-1H-benzimidazol-2-yl) carbamate is poorly soluble in water. This drug is a benzimidazole derivative with a broad anthelmintic spectrum used for the treatment of neurocysticercosis, echinococcosis, giardiasis and filariasis [1-3]. Its poor bioavailability, cause an unpredictable therapeutic response in some parasitic infections. ALB microparticles based on ternary polymeric systems have been formulated by Chitosan (CH), Pectin (P) and Sodium Carboxymethylcellulose (CMC Sodium) to increase the dissolution rate and to improve the bioavailability parameters. These polymers formed a polyelectrolyte complex (PEC) matrix for drug delivery. P is an anionic polysaccharide widely explored as a drug transporter. CH is a cationic polymer soluble in dilute acid solutions which presents excellent biocompatibility, complete biodegradability and low toxicity among other properties.