Development and full characterization of chitosan-carbopol matrix for the delivery of antifungal agents

REAL, D.; MARTINEZ, M.V.; FRATTINI, A.; SOAZO, M.; SALOMON, C.J.; OLIVIERI, A.C.; LEONARDI, D.

Rosario

Congreso; II Reunión Internacional de Ciencias Farmacéuticas RICIFA 2012; 2012

Chitosan (CH) is a cationic biocompatible polymer usually employed as drugs carrier. CH can be the matrix for microparticles, nanoparticles, or films, among others. Mechanical properties of CH matrixes may be improved when CH forms complexes with other oppositely charged Carbopol 971NF (CB) is an anionic polymer frequently employed in drug delivery gel systems for buccal, trans dermic, ocular, rectal, and nasal applications. The interaction between the polymers may produce a polymeric matrix which could be able to transport and release different drugs. Thus, the aims of this work was the development of polymeric matrixes loaded with econazole nitrate (ECN) as model drug, and the full characterize these systems.