13C and15N solid-state NMR studies on albendazole and cyclodextrin albendazole complexes

FERREIRA M.; GARCÍA A; LEONARDI D; SALOMON CJ; LAMAS M.C.; NUNEZ T

CARBOHYDRATE POLYMERS

ELSEVIER SCI LTD

Lugar: Amsterdam; Año: 2015 vol. 123 p. 130 - 135

0144-8617

13C and15N solid-state nuclear magnetic resonance (NMR) spectra were recorded from albendazole (ABZ) and from ABZ:b-cyclodextrin, ABZ:methyl- b-cyclodextrin, ABZ:hydroxypropyl- b-cyclodextrinand ABZ:citrate- b-cyclodextrin, which were prepared by the spray-drying technique. ABZ signals were typical of a crystalline solid for the pure drug and of an amorphous compound obtained from ABZ:cyclodextrin samples. Relevant spectral differences were correlated with chemical interaction between ABZ and cyclodextrins. The number and type of complexes revealed a strong dependence on the cyclodextrin group substituent. Solid-state NMR data were consistent with the presence of stable inclusion complexes.