RAPISARDA Viviana Andrea
congresos y reuniones científicas
PREVALENCE OF UROPATHOGENS ISOLATED FROM IN AND OUTPATIENTS AT THE ANGEL C. PADILLA HOSPITAL IN SAN MIGUEL DE TUCUMÁN. ANTIBIOTIC SUSCEPTIBILITY PROFILES
ORDOÑEZ-CLEMENTE, A; RECÚPERO, AM; CÁCERES, MA; RAPISARDA, VA; VILLEGAS, J M; GRILLO PUERTAS, M
Congreso; SAIB-SAMIGE Joint meeting 2021; 2021
Urinary tract infections (UTI) are the most frequent infections in the hospital setting and the general community. In the past decade, about seven million outpatient medical consultations were accounted about UTI, and ~ one million annual hospitalizations, representing a billion dollars cost per year in USA. Despite the UTI high prevalence, the diversity of associated microorganisms and their negative impacts on public health costs, studies about this subject in Argentina, particularly in Tucumán, are scarce. It is essential to have up-to-date local information on the most prevalent circulating etiological agents and its associated resistance profile, which would allow a better empirical management of UTI. Thus, the aim of this work was to determine the prevalence of uropathogens related to UTI and its antimicrobial susceptibility in out and inpatients of the Ángel C. Padilla Hospital in San Miguel de Tucumán. Midstream urine samples from patients with signs and symptoms of UTI during November 2019 to October 2020 were collected at the bacteriology laboratory of the hospital and cultured. Isolate identification and antibiotic susceptibility were performed with the Vitek automated system. A retrospective descriptive study with a quantitative approach was carried out, obtaining valid information from positive urine culture reports of 701 patients. More than 54% of the cases correspond to hospitalized patients (381); the rest was the outpatient sector (320). The UTI prevalence was higher among females (62%) compared to males (38%), with an average age of 48 years old. Escherichia coli was identified as the main etiological agent of UTI (53.5%), followed by Klebsiella pneumoniae (13.4%), Proteus mirabilis (8.4%), Enterococcus faecalis (3.3%), K. aerogenes (3.0%), Pseudomonas aeruginosa (1.9%), Staphylococcus aureus (1.8%) and S. epidermidis (1.6%). Among the evaluated antibiotics, most etiological agents showed the highest percentage of resistance to Ampicillin (78%), followed by Ciprofloxacin (47.9%) and Trimethoprim / Sulfamethoxazole (50.6%). On the other hand, the antibiotic with the highest effectiveness was Imipenem (98%), Amikacin (94%) and Meropenem (91.5%). E. coli isolates showed a higher frequency of resistance to Ampicillin (72.9%), Ciprofloxacin (54.6%), and Trimethoprim-Sulfamethoxazole (49.1%). In contrast, isolates were more sensitive to Imipenem (0.4%), Amikacin (1.5%) and Nitrofurantoin (2.2%). K. pneumonia also showed resistance to Cephalexin (57%) and Cefotaxime (53.5%). Among all tested bacteria, only P. mirabilis and K. aerogenes isolates showed multidrug resistance. The obtained results will allow us to generate a preliminary UTI clinical-epidemiological profile of Tucumán city, providing relevance data to different areas of clinical practice.