Tiotidine, a classical H2-antagonist, presents characteristics of an inverse agonist in U937 cell line.

MONCZOR FEDERICO; LEGNAZZI BL; RIVERA ELENA; DAVIO CARLOS

INFLAMMATION RESEARCH

Birkhäuser

Lugar: Basilea; Año: 1998 vol. 47 p. 42 - 43

1023-3830

It is generally accepted that the histamine H2 receptor is coupled to the adenylyl cyclase system through direct interaction with a Gs protein family. In the histiocytic lymphoma cell line U937, a histamine H2 receptor wasdescribed that directly increases cyclic AMP production with a classical pharmacological profile. Recently it was found that drugs classically considered as antagonists, behave in some systems as inverse agonists. The purpose of the present work was to study the tiotidine pharmacological characteristics in U937 cell line.