INVESTIGADORES
GOLDBAUM Fernando Alberto
artículos
Título:
Immune response and serum bactericidal activity against Brucella ovis elicited using a short immunization schedule with the polymeric antigen BLSOmp31 in rams
Autor/es:
DÍAZ AG, CLAUSSE M, PAOLICCHI FA, FIORENTINO MA, GHERSI G, ZYLBERMAN V, GOLDBAUM FA AND ESTEIN SM.
Revista:
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2013 vol. 154 p. 36 - 41
ISSN:
0165-2427
Resumen:
Brucella ovis is the etiologic agent of ovine brucellosis. The control
measures for this disease are periodical diagnosis by serological tests
and/or bacteriological culture and culling of positive animals.
Vaccination with Brucella melitensis Rev 1 is recommended when
prevalence is high. This attenuated strain vaccine gives protection
against B. ovis but it has important disadvantages associated with the
development of antibodies interfering with serodiagnosis, virulence for
humans and the prohibition of its use in countries considered free of B.
melitensis. Consequently, there is a need for new safe and effective
brucellosis vaccines to be developed. We have previously reported that
the polymeric subcellular vaccine BLSOmp31 confers protection against
experimental challenge with B. ovis when rams are immunized three times.
In the present work we evaluated and characterized, along 56 weeks
after the first immunization of adult rams, the evolution of the immune
response elicited by BLSOmp31 using a short immunization schedule.