Antioxidant and xanthine oxidase inhibitory activities of plant species from the Argentine Puna (Antofagasta, catamarca).

ZAMPINI I.C, MESON GANA J., ORDOÑEZ R.M., SAYAGO J.E., NIEVA MORENO M.I., ISLA M.I.

Recent Progress in Medicinal Plants.

STUDIUM PRESS LLC, U.S.A.

Lugar: India; Año: 2008; p. 95 - 110

The antioxidant and xanthine oxidase inhibitory activities of extract of plants (Baccharis boliviensis, Baccharis incarum, Chuquiraga atacamensis and Parastrephia lucida) collected at 3800 meters above sea level, in the Argentine Puna were studied. The TEAC values ranged from 4,100 to 15,588 µmol Trolox equivalent /100 g dry weight. All extracts exerted higher hydrogen donating ability in the presence of DPPH radicals. In the non-enzymatic system of O2- generation, extracts were scavengers of superoxide radicals with IC50 values between 10 - 20 µg of total phenolic compounds/mL. The B. boliviensis, B. incarum and P. lucida extracts were effective hydroxyl radical scavengers with IC50 values of 6, 13.5 and 27 µg/mL, respectively.  B. incarum was the best H2O2 scavenger with IC25 values of 30 µg/mL. Flavones may be responsible for this antioxidant capacity. All assayed extracts were xanthine oxidase inhibitors. The active extracts may be exploited as natural medicine to reduce oxidative stress and for the prevention and treatment of hyperuricemia.