CONICET | Buscador de Institutos y Recursos Humanos

Solid state phenomena are relevant to the pharmaceutical industry since changes that24 take place during manufacture or storage of pharmaceutical formulations can affect critical25 properties of the products. Dissolution monitoring is a critical parameter for pharmaceutical26 solid forms since it is finally related to active bioavailability and activity (or side effects).27 Both solid-state and dissolution are closely correlated since dissolution performance usually28 depends of solid forms to be tested. However, unexpected transformation may occur when29 solid for take contact to dissolution media complicating the panorama.30 The dissolution behavior of MBZ C, MBZ·M and MBZ·HCl was studied by a dual31 characterization of the phenomena, dissolution and solid transformation. The monitoring of32 dissolution was carried out by employing UV on-line measurements; solid residues were33 withdrawn during the experiments and monitored at-line by ATR-FTIR spectroscopy.34 Chemometric method MCR-ALS was applied to deconvolute the corresponding FTIR spectra.35 Both salts were partially dissolved in dissolution medium showing higher dissolution36 profiles than form C. MBZ·M remaining solid immediately transforms to MBZ C, while that37 coming from MBZ·HCl undergoes a gradual conversion to form C after a pseudo-equilibrium38 phase (40-60 min). This results are on full accord with MBZ·HCl dissolution profile, that39 exhibits high concentrations up to the first 30 min and a gradual descent between 40-60 min.40 No transformations were observed in MBZ C suspended solid during the dissolution test.41 MBZ·M and MBZ·HCl improve the solubility of MBZ but both in contact with 0.1 M42 HCl convert to form C, MBZ·HCl being the salt most favored in terms of solubility and43 stability.