INTEQUI 20941
INSTITUTO DE INVESTIGACIONES EN TECNOLOGIA QUIMICA
Unidad Ejecutora - UE
artículos
Título:
Modular total syntheses of thymifodioic/incanic acids
Autor/es:
TONN, C.E.; ALVAREZ MÉNDEZ, SERGIO; MARTÍN, V.S.; SAAD, J.R.; GARCÍA, C.
Revista:
Arabian Journal of Chemistry
Editorial:
Elsevier
Referencias:
Año: 2020 vol. 12 p. 3764 - 3775
ISSN:
1878-5352
Resumen:
Abstract:The first total synthesis of the bioactive natural product 2,6-(E,E)-thymifodioic acid, also called incanic acid, and its stereoisomers is described. An unified, iterative and modular strategy was envisioned, achieving the synthesis of the goals products after five reaction steps in an overall yield ranging from 8% to 16%. The key step is a non-expensive easy to perform Horner?Wads worth?Emmons condensation.
