INTEQUI 20941
INSTITUTO DE INVESTIGACIONES EN TECNOLOGIA QUIMICA
Unidad Ejecutora - UE
artículos
Título:
Tessaric Acid Derivatives Induce G2/M Cell Cycle Arrest in Human Solid Tumor Cell Lines
Autor/es:
LEÓN, L.G.; DONADEL, O.J.; TONN, C.E.; PADRÓN, J.M.
Revista:
BIOORGANIC & MEDICINAL CHEMISTRY.
Editorial:
Pergamon
Referencias:
Año: 2009 p. 6251 - 6259
ISSN:
0968-0896
Resumen:
Abstract A series of analogs were synthesized in a straightforward manner from naturally available sesquiterpenes ilicic acid and tessaric acid. The in vitro antiproliferative activities were examined in the human solid tumor cell lines A2780, HBL-100, HeLa, SW1573, T-47D and WiDr. The most potent analog induced considerably growth inhibition in the range 1.94.5 M. Cell cycle studies for tessaric acid derivatives indicated a prominent arrest of the cell cycle at the G2/M phase. Damage to the cells was permanent as determine by the so called 24+24 drug schedule.
