INTEQUI 20941
INSTITUTO DE INVESTIGACIONES EN TECNOLOGIA QUIMICA
Unidad Ejecutora - UE
artículos
Título:
Structure-Antifungal Activity Relationship of Related Cinnamic Acid Derivatives
Autor/es:
BISOGNO FR; MASCOTTI ML; SANCHEZ C; GARIBOTTO F; GIANNINI FA; KURINA SANZ MB; ENRIZ RD
Revista:
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Editorial:
American Chemical Society
Referencias:
Año: 2007 p. 10636 - 10640
ISSN:
0021-8561
Resumen:
Abstract: A structure-antifungal activity relationship (SAR) study of 23 related cinnamic acid derivatives was carried out. Attention was focused on the antifungal activities exhibited against Aspergillus flavus, Aspergillus terreus and aspergillus niger. (E)-3-(4-methoxy-3-(3-methylbut-2-enyl)phenyl) acrylic acid (compound 16) exhibited antifungal activity against A. niger, comparable to that of miconazole and a significant antifungal effect against A. Flavus and A. terreus as well. A structure-activity relationship (SAR) study of related cinnamic acid derivatives have allowed a model to be proposed for the recognition of the minimal structural requirements for the antifungal effect.
