INTEQUI 20941
INSTITUTO DE INVESTIGACIONES EN TECNOLOGIA QUIMICA
Unidad Ejecutora - UE
artículos
Título:
Cytotoxic Bioactivity of some Phenylpropanoic Acid Derivatives
Autor/es:
RETA, G.F.; TONN, C.E.; RIOS-LUCI, C; LEON, L. ; PÉREZ-ROTH, E.; PADRÓN, J.M.; DONADEL, O.J.
Revista:
NATURAL PRODUCT COMMUNICATIONS
Editorial:
NATURAL PRODUCTS INC
Referencias:
Lugar: Westerville, Ohio; Año: 2012 vol. 7 p. 1341 - 1346
ISSN:
1934-578X
Resumen:
In this study, we synthesized a series of phenylpropanoic acid derivatives based on modifications at four selected points of the molecular scaffold. The in vitro antiproliferative activities of the compounds were examined in representative human solid tumor cell lines. A SAR was established pointing out the relevance of the substituents. The best activity profiles were obtained for the derivatives bearing more lipophilic esters (GI50 3.1-21 μM).
