INTEQUI 20941
INSTITUTO DE INVESTIGACIONES EN TECNOLOGIA QUIMICA
Unidad Ejecutora - UE
artículos
Título:
IN VITRO SPERMATOSTATIC ACTIVITY BY MULENANE- AND AZORELLANE-TYPE DITERPENES ON HUMAN SPERMATOZOA
Autor/es:
ALEJANDRA I. CHIARAMELLO, ROBERTO YUNES, PEDRO C. ROSSOMANDO & DIEGO A. CIFUENTE
Revista:
ACTA FARM. BONAERENSE
Editorial:
COLEGIO FARMACEUTICOS PROVINCIA DE BUENOS AIRES
Referencias:
Año: 2011 vol. 30 p. 1325 - 1329
ISSN:
0326-2383
Resumen:
Mulinenic acid (1), mulinolic acid (2) and azorellan-17,13-(â)olide (3) isolated from Mulinum spinosum and Azorella trifurcata have been evaluated for their spermatostatic activity on human spermatozoa. In vitro sperm motility, viability and recovery of the motility were assessed. Compounds 2 and 3 showed significant spermatostatic properties. Reversible effects for 2 (% Motile Cells = 32 ± 3, % Living Cells = 84 ± 4) and irreversible effects for 3 (% Motile Cells = 34 ± 4, % Living Cells = 82 ± 4) were observed. Compound 1 showed moderate bioactivity. Compounds 2-3 presented remarkable effects on human sperm motility and we were encouraged to consider their application as a potential non hormonal male contraceptive agent.
