Dendritic cells in the immunopathological scenario of reactive arthritis

, DI GENARO MS

San Miguel de Tucumán

Congreso; LVII REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE INMUNOLOGÍA; 2019

Dendritic cells in the immunopathological scenario of reactive arthritis Di Genaro, María SilviaReactive arthritis (ReA) is a form of peripheral spondyloarthritis (SpA) that develop 1-3 weeks after a gastrointestinal or urogenital infection. Once ReA is detected, bacterial cultures of synovial fluids are negative. Dendritic cells (DCs) participate in the pathogenesis of a range of diseases, including the joint inflammation and progression of rheumatoid arthritis. However, the DC involvement in the onset of reactive arthritis (ReA) remains unclear. We investigated DCs in a murine model of Yersinia enterocolitica O:3-induced ReA in TNFRp55-/- mice. We demonstrated that DCs participate in IL-12/23p40 overproduction, which leads to increased Th1 and Th17 polarization. In addition, we provide data that indicate that the migration of intestinal DCs to the regional lymph nodes of the joints contributes to the immunopathogenesis of ReA.