CADMIUM INTOXICATION IN CEREBELLUM: EFFECT OF DIFFERENT EXPOSITION TIMES AND PROTEIN SOURCES

MARTIN MOLINERO GD; BOLDRINI GG; ALVAREZ SM; GIMENEZ MS

MERLO, San Luis

Congreso; Reunión Anual de la Sociedad De Biología de Cuyo; 2017

SOCIEDAD DE BIOLOGIA DE CUYO

Cadmium (Cd) is an environmental contaminant. We studied its effect on cerebellum at different exposition times and protein diets. Oxidative stress, lipid and apoptotic markers were determined. 4 lots of female Wistar rats were used: 2 lots received casein (Cas) and 2 lots soybean (Soy) as protein source, one lot received regular water (Co) and one, 15ppm of Cd in the drinking water for 30 (30d) and 60 days (60d). SOD 2, Nrf-2, NOX 2, Gpx, p47, ACC, HMGCoAR, DGAT, Bax, Bcl-2 were determined by PCR. S28 was the internal control. Nrf-2 and Gpx increased in CasCd at 30d, decreasing in Cd groups (p