OVERNUTRITION INDUCES NEURO-ONTOGENY CHANGES IN OFFSPRING BEHAVIOR PATTERNS.

SOLER GARCIA FLORENCIA M; FUENTES LUCIA BEATRIZ; GARCÍA SILVINA; SANCHEZ SUSANA INES

Mendoza

Congreso; XXXIV REUNION CIENTIFICA ANUAL DE LA SOCIEDAD DE BIOLOGIA DE CUYO; 2016

Sociedad de Biología de Cuyo

Altered nutritional experience during the lactancyperiod can impact on offspring health.Several studies have investigated the effects of artificial litter size adjustment on development.Electrophysiological studies performed on coronal slices obtained from brains of small litter (SL) and age-matched normal litter (NL) rats revealed significant changes in the response to various stimuli/inhibitors. The aim of this study was toinvestigate if neurobehavioraldevelopment in the pup was affected by the size of the litter. Wistar rat litters were divided into two groups:NL (11±1 pups) andSL (were adjusted gradually, 2-3 pupswere sacrificed in 0, 3, 5, 7, 15 postnatal days). The pupswere carried to the testing laboratory, identified and weighed.The spontaneousneurobehavioralpatterns were determined in an open field. SL offspring exhibited significant increased weight at the end of first postnatal week (SL: 15.8 ±0.3 g vs NL: 13.3±0.3 g, p˂0.01) and second postnatal week (SL: 32.3 ±2.4 g vs NL:23.0±1.0 g, p˂0.001).The open field test at postnatal day 15 shows significant increase time exploratory behavior in SL vs NL ( 59.4 ±7.5% vs 33.34 ±4.1 %, p˂0.01),square crossing ( 40.0 ±4.8 sq vs 18.0±3.1 sq, p˂0.02) and significant decrease grooming (3.2 ±1.0% vs 15.5 ±4.8%, p˂0.01).Our result indicatedadvance maturation landmarks in SL litter due to a change the neuro-ontogeny of the rat behavior patterns which could be direct influence of overnutrition.