Correlación entre parámetros clínicos y de estrés oxidativo en la población infantil obesa de la ciudad de San Luis

SANTILLÁN L., GIMÉNEZ M.S

Mendoza

Congreso; XXVIII Reunión Científica Anual de la Sociedad de Biología de Cuyo; 2010

Correlación entre parámetros clínicos y de estrés oxidativo  en la población infantil obesa de la ciudad de San Luis. Autores: Santillán L., Giménez M.S. Presentado en la XXVIII Reunión Científica                                                                  Anual de la Sociedad de Biología de Cuyo, Octubre de 2010. Mendoza. Argentina y    publicado en Rev. Biocell Resúmen: The increased oxidative stress (OS) may be involved in the pathogenesis of cardiovascular disease (CHD). In obese children increased ROS causes a decrease in antioxidant enzyme activity (AE). The purpose of this study was to investigate the association between body mass index (BMI) and its relationship with expression of mRNANRF-2, activity of AE, OS and clinical parameters in obese children. Blood was drawn from 27 non-obese children and 31 obese patients. Plasma was separated and determined fasting glucose (FG), total cholesterol (TC), HDLc, LDLc, triglycerides (TG), HOMA, diastolic (DBP) and systolic pressure (SBP), TBARS, paraoxonase (PON), glutathione peroxidase (GPx) and catalase (CAT) as well as RT-PCR was performed for quantification of NRF-2. Pearson index determined for the correlations studied revealed a positive correlation between BMI and TC, TG, HDL-C, TBARS, HOMA, systolic pressure and negative correlation between BMI and HDL, AE activity and expression of NRF-2. In Obese children altering the balance of OS contribute to an increased risk of CHD.