Efecto disruptor del extracto metanólico de frutos Prosopis torquata (CAV. EX LAG.) sobre ratas machos Wistar

DÍAZ, YESICA; SALINAS ADRIANA; AGUILERA-MERLO, CLAUDIA; CARRASCO MIRTA; ANTONIO MANGIONE

Revsita Mexicana de Ciencias Farmaceuticas

Asociación Farmacéutica Mexicana

Año: 2015 vol. 46

Endocrine disruptors from plants cause anomalies in the reproductive system of mammals. We studied the eects of methanolic extract (MEx) from the Prosopis torquata fruit on the reproductive functions, histology and morphology of thereproductive system of male Wistar rats. Ospring were randomly distributed in four groups. Three with a phytoestrogen-free diet and injected subcutaneously with MEx, estradiol (E) and vehicle (Ve), respectively. The fourth was fed with a commercial diet containing phytoestrogens (Cf + Ve). No signicant changes were observed in hormones values and in the sperm concentration between the groups. The MEx group exhibited a slower testicle maturation, scarce number of elongated spermatids, and epithelial disorganization in the reproductive organs. Disruptive eect of MEx hasbeen observed in our laboratory on female Wistar rats.