Cytotoxic and antifungal activities of diverse α-naphthylamine derivatives

VLADIMIR V. KOUZNETSOV; SUSANA A. ZACCHINO; MAXIMILANO SORTINO; LEONOR Y. VARGAS; MAHABIR GUPTA

Scientia pharmaceutica

Osterreichische Apotheker-Verlagsgessellschaft

Año: 2012 vol. 80 p. 867 - 877

0036-8709

Diverse α-naphthylamine derivatives were easily prepared from corresponding aldimines derived from commercially available á-naphthaldehyde and anilines or isomeric pyridinecarboxyaldehydes and á-naphthylamine. The secondary amines obtained were tested as possible antifungal and cytotoxic agents. The diverse N-aryl-N-[1-(1-naphthyl)but-3-enyl]amines obtained were active (IC50 < 10 µg/mL) against breast (MCF-7), non-small cell lung (H-460), and central nervous system (SF-268) human cancer cell lines, while N-(pyridinylmethyl)-naphthalen-1-amines resulted in activity against (MIC 25–32 µg/mL) some human opportunistic pathogenic fungi including yeasts, hialohyphomycetes, and dermatophytes.