IFEC 20925
INSTITUTO DE FARMACOLOGIA EXPERIMENTAL DE CORDOBA
Unidad Ejecutora - UE
artículos
Título:
Intra-amygdaloid microinjection of neuropeptide glutamic acid-isoleucine induces anxiety-like behavior
Autor/es:
GASTON SOLEDAD; GARGIULO PASCUAL A.; BREGONZIO CLAUDIA; BAIARDI GUSTAVO
Revista:
NEUROREPORT
Editorial:
LIPPINCOTT WILLIAMS & WILKINS
Referencias:
Año: 2010
ISSN:
0959-4965
Resumen:
The amygdaloid complex is involved in anxiety or fearresponses to stressful stimuli. In this study the effect ofneuropeptide-EI on anxiety-like behavior and its influenceon adrenocortical function was tested in male Wistar ratsthat were injected bilaterally in the basolateral amygdalawith neuropeptide-EI (1 lg/1 ll) or artificial cerebrospinalfluid and placed on the plus maze. The plasmacorticosterone levels were analyzed in controls and plusmazeexposed animals. Neuropeptide-EI in the basolateralamygdala significantly decreased the time spent in openarms but had no effect on locomotor activity, showing ananxiogenic effect. However, neuropeptide administrationdid not change serum corticosterone levels compared withvehicle controls. Our results suggest that the anxiogeniceffect of neuropeptide-EI could be independent ofthe hypothalamicpituitaryadrenocortical systemresponse. NeuroReport 00:000000
