IFEC 20925
INSTITUTO DE FARMACOLOGIA EXPERIMENTAL DE CORDOBA
Unidad Ejecutora - UE
artículos
Título:
Sauroine, a Lycopodium alkaloid that enhances memory
Autor/es:
MARIANA VALLEJOS; GABRIELA ORTEGA; JOSE CABRERA; VALERIA CARLINI; SUSANA RUBIALES DE BARIOGLIO; ROMINA ALMIRON; OSCAR RAMIREZ; MARIEL AGNESE
Revista:
JOURNAL OF NATURAL PRODUCTS
Editorial:
ACS publications
Referencias:
Año: 2009 vol. 72 p. 156 - 158
ISSN:
0163-3864
Resumen:
The present study intends to determine the effect of sauroine (1), the main alkaloid obtained from Huperzia saururus (Lam.) Trev. on memory retention and learning. To evaluate this, electrophysiological experiments and behavioral tests (step down) were performed. Results show that 1 improves memory retention in the step-down test, significantly increasing hippocampal plasticity. Thus, 1 seems to be one of the compounds responsible for the H. saururus activity claimed in folk medicine.
