IFEC   20925
INSTITUTO DE FARMACOLOGIA EXPERIMENTAL DE CORDOBA
Unidad Ejecutora - UE
artículos
Título:
Central Ghrelin increases anxiety in open field and impairs retention memory in passive avoidance task in neonatal chicks.
Autor/es:
CARAVAJAL PEDRO; CARLINI VALERIA; SCHIÖTH HELGI; RUBIALES DE BARIOGLIO, SUSANA ELIZABETH; SALVATIERRA NANCY
Revista:
NEUROBIOLOGY OF LEARNING AND MEMORY
Editorial:
Elsevier
Referencias:
Año: 2009 vol. 91 p. 402 - 407
ISSN:
1074-7427
Resumen:
Ghrelin (Grh) is an endogenous ligand for the growth hormone secretagogue receptor. Although Ghr
stimulates feeding in rats, it inhibits feeding in neonatal chicks. However, little is known about other central
behavioral effects of Ghr. Therefore, we investigated the Ghr effects, injected intracerebroventricularly,
on anxiety and memory retention of neonatal chicks in an Open Field test and in a one-trial passive
avoidance task, respectively. In the Open Field test, the administration of Ghr in a dose-dependent manner
increased the latency to ambulate but decreased ambulation activity, indicating an anxiogenic effect.
Furthermore, chicks trained on a passive avoidance task and injected with a dose of 30 pmol of Ghr
immediately after training showed an impairment of memory retention. However, there were no significant
effects on the number of pecks during the pretraining, training, retention and discrimination. In
addition, different doses of Ghr produced an inhibition in food intake at different times after injection.
Our results indicate that Ghr induces anxiogenesis in chicks. Moreover, we have shown for the .rst time
that Ghr can decrease memory retention in a non-mammalian species, suggesting that Ghr may play an
important role in the processes of memory retention in birds.