IFEC   20925
INSTITUTO DE FARMACOLOGIA EXPERIMENTAL DE CORDOBA
Unidad Ejecutora - UE
artículos
Título:
Previous stress exposure enhances both anxiety-like behaviour and p35 levels in the basolateral amygdala complex: modulation by midazolam
Autor/es:
ANAHI BIGNANTE, GABRIELA PAGLINI AND VICTOR ALEJANDRO MOLINA
Revista:
EUROPEAN NEUROPSYCHOFARMACOLOGY
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Año: 2010 vol. 20 p. 388 - 397
ISSN:
0924-977X
Resumen:
Stress exposure induces long lasting neurobiological changes in selected brain areas, which could
be associated with the emergence of negative emotional responses. In the present study,
previously restrained animals exhibited excessive anxiety one day later in the elevated plus
maze. We explore whether stress exposure affects the expression levels of cyclin-dependent
kinase 5 (Cdk5) and of its activator protein p35, in diverse amygdaloid nuclei. Stress exposure
enhanced p35 levels selectively in the basolateral amygdala (BLA). This up-regulation might be
functionally associated with the occurrence of exaggerated anxiety since such emotional
response was selectively reversed by an intra-BLA infusion of olomoucine, a Cdk5 inhibitor,
15 min prior to the restraint session. Moreover, pre-treatment with midazolam, a benzodiazepine
ligand, not only prevented the excessive anxiety but also attenuated the p35 increase in
the BLA of stressed rats. In conclusion, we suggest a pivotal role of the Cdk5/p35 complex,
specifically in BLA in the excessive anxiety induced by a previous stressful experience.