Aldehyde dehydrogenase 2 in the spotlight: The link between mitochondria and neurodegeneration

HEREÑÚ, CLAUDIA BEATRIZ; HERRERA, MACARENA LORENA; VIRGOLINI, MIRIAM BEATRIZ; DEZA-PONZIO, ROMINA; BELLINI, MARÍA JOSÉ

NEUROTOXICOLOGY

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2018 vol. 68 p. 19 - 24

0161-813X

Growing body of evidence suggests that mitochondrial dysfunctions andresultant oxidative stress are likely responsible for many neurodegenerative diseases,including Alzheimer´s disease (AD) and Parkinson´s disease (PD). Aldehydedehydrogenase (ALDH) superfamily plays a crucial role in several biological processesincluding development and detoxification pathways in the organism. In particular,ALDH2 is crucial in the oxidative metabolism of toxic aldehydes in the brain, such ascatecholaminergic metabolites (DOPAL and DOPEGAL) and the principal product oflipid peroxidation process 4-HNE. This review aims to deepen the current knowledgeregarding to ALDH2 function and its relation with brain-damaging processes thatincrease the risk to develop neurodegenerative disorders. We focused on relevantliterature of what is currently known at molecular and cellular levels in experimentalmodels of these pathologies. The understanding of ALDH2 contributions could be apotential target in new therapeutic approaches for PD and AD due to its crucial role inmitochondrial normal function maintenance that protects against neurotoxicity