IFEC   20925
INSTITUTO DE FARMACOLOGIA EXPERIMENTAL DE CORDOBA
Unidad Ejecutora - UE
artículos
Título:
Memory consolidation and reconsolidation in an invertebrate model: The role of the GABAergic system
Autor/es:
CARBÓ TANO, M; MOLINA, VA; MALDONADO, H. AND M.E.PEDREIRA.
Revista:
NEUROSCIENCE
Editorial:
Elsevier Science
Referencias:
Lugar: EE.UU; Año: 2009 vol. 158 p. 387 - 401
ISSN:
0306-4522
Resumen:
Consolidation theory assumes that memories are
labile during a limited time window after acquisition, but as
time passes, memories become stable and resistant to amnesic
agents. However, the vision of immutable memories
after consolidation has been challenged. Thus, after the presentation
of a reminder, the reactivated old memories become
labile and again susceptible to amnesic treatments.
This process implies a re-stabilization phase, usually referred
to as reconsolidation.
Gamma-aminobutyric acid (GABA) is the major inhibitory
neurotransmitter both in the Central nervous system (CNS)
and in the periphery. A considerable amount of evidence has
arisen from different studies regarding the role of the GABAAA
receptor in diverse behavioral paradigms and tasks. Here, we
investigate the role of the GABAergic system on both memory
consolidation and reconsolidation phases by using the
memory paradigm of the crab Chasmagnathus. In order to
achieve such a goal, we design pharmacological-behavioral
experiments, which include the administration of classic agonist
(muscimol) and antagonist (bicuculline) of the mammals
GABAA receptors. The current results show that the
systemic administration of muscimol impairs the consolidation
and reconsolidation processes. In contrast, the administration
of bicuculline improves the consolidation and reconsolidation
processes. Furthermore, the co-administration
of both drugs blocks the agonist amnesic effect on the consolidation
phase.
The ubiquity of the neurotransmitter and its receptors in
the animal taxa allows us to use the classic agonist-andantagonist
administration procedure in this invertebrate.
Thus, all the results reported in this paper can be judged as
a result of the modulation exerted by the functional state of
the GABAergic system in the CNS.
To conclude, the results obtained in this report with an
invertebrate model represent additional evidences supporting
the view that some molecular mechanisms subserving
different memory phases could be the basic tools employed
by phylogenetically disparate animals.
a result of the modulation exerted by the functional state of
the GABAergic system in the CNS.
To conclude, the results obtained in this report with an
invertebrate model represent additional evidences supporting
the view that some molecular mechanisms subserving
different memory phases could be the basic tools employed
by phylogenetically disparate animals.
a result of the modulation exerted by the functional state of
the GABAergic system in the CNS.
To conclude, the results obtained in this report with an
invertebrate model represent additional evidences supporting
the view that some molecular mechanisms subserving
different memory phases could be the basic tools employed
by phylogenetically disparate animals.
systemic administration of muscimol impairs the consolidation
and reconsolidation processes. In contrast, the administration
of bicuculline improves the consolidation and reconsolidation
processes. Furthermore, the co-administration
of both drugs blocks the agonist amnesic effect on the consolidation
phase.
The ubiquity of the neurotransmitter and its receptors in
the animal taxa allows us to use the classic agonist-andantagonist
administration procedure in this invertebrate.
Thus, all the results reported in this paper can be judged as
a result of the modulation exerted by the functional state of
the GABAergic system in the CNS.
To conclude, the results obtained in this report with an
invertebrate model represent additional evidences supporting
the view that some molecular mechanisms subserving
different memory phases could be the basic tools employed
by phylogenetically disparate animals.
a result of the modulation exerted by the functional state of
the GABAergic system in the CNS.
To conclude, the results obtained in this report with an
invertebrate model represent additional evidences supporting
the view that some molecular mechanisms subserving
different memory phases could be the basic tools employed
by phylogenetically disparate animals.
a result of the modulation exerted by the functional state of
the GABAergic system in the CNS.
To conclude, the results obtained in this report with an
invertebrate model represent additional evidences supporting
the view that some molecular mechanisms subserving
different memory phases could be the basic tools employed
by phylogenetically disparate animals.
achieve such a goal, we design pharmacological-behavioral
experiments, which include the administration of classic agonist
(muscimol) and antagonist (bicuculline) of the mammals
GABAA receptors. The current results show that the
systemic administration of muscimol impairs the consolidation
and reconsolidation processes. In contrast, the administration
of bicuculline improves the consolidation and reconsolidation
processes. Furthermore, the co-administration
of both drugs blocks the agonist amnesic effect on the consolidation
phase.
The ubiquity of the neurotransmitter and its receptors in
the animal taxa allows us to use the classic agonist-andantagonist
administration procedure in this invertebrate.
Thus, all the results reported in this paper can be judged as
a result of the modulation exerted by the functional state of
the GABAergic system in the CNS.
To conclude, the results obtained in this report with an
invertebrate model represent additional evidences supporting
the view that some molecular mechanisms subserving
different memory phases could be the basic tools employed
by phylogenetically disparate animals.
a result of the modulation exerted by the functional state of
the GABAergic system in the CNS.
To conclude, the results obtained in this report with an
invertebrate model represent additional evidences supporting
the view that some molecular mechanisms subserving
different memory phases could be the basic tools employed
by phylogenetically disparate animals.
a result of the modulation exerted by the functional state of
the GABAergic system in the CNS.
To conclude, the results obtained in this report with an
invertebrate model represent additional evidences supporting
the view that some molecular mechanisms subserving
different memory phases could be the basic tools employed
by phylogenetically disparate animals.
systemic administration of muscimol impairs the consolidation
and reconsolidation processes. In contrast, the administration
of bicuculline improves the consolidation and reconsolidation
processes. Furthermore, the co-administration
of both drugs blocks the agonist amnesic effect on the consolidation
phase.
The ubiquity of the neurotransmitter and its receptors in
the animal taxa allows us to use the classic agonist-andantagonist
administration procedure in this invertebrate.
Thus, all the results reported in this paper can be judged as
a result of the modulation exerted by the functional state of
the GABAergic system in the CNS.
To conclude, the results obtained in this report with an
invertebrate model represent additional evidences supporting
the view that some molecular mechanisms subserving
different memory phases could be the basic tools employed
by phylogenetically disparate animals.
a result of the modulation exerted by the functional state of
the GABAergic system in the CNS.
To conclude, the results obtained in this report with an
invertebrate model represent additional evidences supporting
the view that some molecular mechanisms subserving
different memory phases could be the basic tools employed
by phylogenetically disparate animals.
a result of the modulation exerted by the functional state of
the GABAergic system in the CNS.
To conclude, the results obtained in this report with an
invertebrate model represent additional evidences supporting
the view that some molecular mechanisms subserving
different memory phases could be the basic tools employed
by phylogenetically disparate animals.
Chasmagnathus. In order to
achieve such a goal, we design pharmacological-behavioral
experiments, which include the administration of classic agonist
(muscimol) and antagonist (bicuculline) of the mammals
GABAA receptors. The current results show that the
systemic administration of muscimol impairs the consolidation
and reconsolidation processes. In contrast, the administration
of bicuculline improves the consolidation and reconsolidation
processes. Furthermore, the co-administration
of both drugs blocks the agonist amnesic effect on the consolidation
phase.
The ubiquity of the neurotransmitter and its receptors in
the animal taxa allows us to use the classic agonist-andantagonist
administration procedure in this invertebrate.
Thus, all the results reported in this paper can be judged as
a result of the modulation exerted by the functional state of
the GABAergic system in the CNS.
To conclude, the results obtained in this report with an
invertebrate model represent additional evidences supporting
the view that some molecular mechanisms subserving
different memory phases could be the basic tools employed
by phylogenetically disparate animals.
a result of the modulation exerted by the functional state of
the GABAergic system in the CNS.
To conclude, the results obtained in this report with an
invertebrate model represent additional evidences supporting
the view that some molecular mechanisms subserving
different memory phases could be the basic tools employed
by phylogenetically disparate animals.
a result of the modulation exerted by the functional state of
the GABAergic system in the CNS.
To conclude, the results obtained in this report with an
invertebrate model represent additional evidences supporting
the view that some molecular mechanisms subserving
different memory phases could be the basic tools employed
by phylogenetically disparate animals.
systemic administration of muscimol impairs the consolidation
and reconsolidation processes. In contrast, the administration
of bicuculline improves the consolidation and reconsolidation
processes. Furthermore, the co-administration
of both drugs blocks the agonist amnesic effect on the consolidation
phase.
The ubiquity of the neurotransmitter and its receptors in
the animal taxa allows us to use the classic agonist-andantagonist
administration procedure in this invertebrate.
Thus, all the results reported in this paper can be judged as
a result of the modulation exerted by the functional state of
the GABAergic system in the CNS.
To conclude, the results obtained in this report with an
invertebrate model represent additional evidences supporting
the view that some molecular mechanisms subserving
different memory phases could be the basic tools employed
by phylogenetically disparate animals.
a result of the modulation exerted by the functional state of
the GABAergic system in the CNS.
To conclude, the results obtained in this report with an
invertebrate model represent additional evidences supporting
the view that some molecular mechanisms subserving
different memory phases could be the basic tools employed
by phylogenetically disparate animals.
a result of the modulation exerted by the functional state of
the GABAergic system in the CNS.
To conclude, the results obtained in this report with an
invertebrate model represent additional evidences supporting
the view that some molecular mechanisms subserving
different memory phases could be the basic tools employed
by phylogenetically disparate animals.
A receptors. The current results show that the
systemic administration of muscimol impairs the consolidation
and reconsolidation processes. In contrast, the administration
of bicuculline improves the consolidation and reconsolidation
processes. Furthermore, the co-administration
of both drugs blocks the agonist amnesic effect on the consolidation
phase.
The ubiquity of the neurotransmitter and its receptors in
the animal taxa allows us to use the classic agonist-andantagonist
administration procedure in this invertebrate.
Thus, all the results reported in this paper can be judged as
a result of the modulation exerted by the functional state of
the GABAergic system in the CNS.
To conclude, the results obtained in this report with an
invertebrate model represent additional evidences supporting
the view that some molecular mechanisms subserving
different memory phases could be the basic tools employed
by phylogenetically disparate animals.
a result of the modulation exerted by the functional state of
the GABAergic system in the CNS.
To conclude, the results obtained in this report with an
invertebrate model represent additional evidences supporting
the view that some molecular mechanisms subserving
different memory phases could be the basic tools employed
by phylogenetically disparate animals.
a result of the modulation exerted by the functional state of
the GABAergic system in the CNS.
To conclude, the results obtained in this report with an
invertebrate model represent additional evidences supporting
the view that some molecular mechanisms subserving
different memory phases could be the basic tools employed
by phylogenetically disparate animals.