IFEC   20925
INSTITUTO DE FARMACOLOGIA EXPERIMENTAL DE CORDOBA
Unidad Ejecutora - UE
artículos
Título:
The involvement of the GABAergic system in the formation and expression of the extinction memory in the crab Neohelice granulate
Autor/es:
CARBO, M.; MOLINA, V.A. AND M.E. PEDREIRA
Revista:
EUROPEAN JOURNAL OF NEUROSCIENCE
Editorial:
WILEY-BLACKWELL PUBLISHING, INC
Referencias:
Lugar: Londres; Año: 2013 vol. 38 p. 3302 - 3313
ISSN:
0953-816X
Resumen:
There is growing interest in the neurobiological mechanisms involved in the extinction of aversive memory. This cognitive process
usually occurs after repeated or prolonged presentation of a conditioned stimulus that was previously associated with an unconditioned
stimulus. If extinction is considered to be a new memory, the role of the c-aminobutyric acid system (GABAergic system)
during extinction memory consolidation should be similar to that described for the original trace. It is also accepted that negative
modulation of the GABAergic system before testing can impair extinction memory expression. However, it seems possible to
speculate that inhibitory mechanisms may be required in order to acquire a memory that is inhibitory in nature. Using a combination
of behavioral protocols, such as weak and robust extinction training procedures, and pharmacological treatments, such as
the systemic administration of GABAA agonist (muscimol) and antagonist (bicuculline), we investigated the role of the GABAergic
system in the different phases of the extinction memory in the crab Neohelice granulata. We show that the stimulation of the
GABAergic system impairs and its inactivation facilitates the extinction memory consolidation. Moreover, fine variations in the
GABAergic tone affect its expression at testing. Finally, an active GABAergic system is necessary for the acquisition of the extinction
memory. This detailed description may contribute to the understanding of the role of the GABAergic system in diverse
aspects of the extinction memory.
GABAergic system impairs and its inactivation facilitates the extinction memory consolidation. Moreover, fine variations in the
GABAergic tone affect its expression at testing. Finally, an active GABAergic system is necessary for the acquisition of the extinction
memory. This detailed description may contribute to the understanding of the role of the GABAergic system in diverse
aspects of the extinction memory.
system in the different phases of the extinction memory in the crab Neohelice granulata. We show that the stimulation of the
GABAergic system impairs and its inactivation facilitates the extinction memory consolidation. Moreover, fine variations in the
GABAergic tone affect its expression at testing. Finally, an active GABAergic system is necessary for the acquisition of the extinction
memory. This detailed description may contribute to the understanding of the role of the GABAergic system in diverse
aspects of the extinction memory.
GABAergic system impairs and its inactivation facilitates the extinction memory consolidation. Moreover, fine variations in the
GABAergic tone affect its expression at testing. Finally, an active GABAergic system is necessary for the acquisition of the extinction
memory. This detailed description may contribute to the understanding of the role of the GABAergic system in diverse
aspects of the extinction memory.
during extinction memory consolidation should be similar to that described for the original trace. It is also accepted that negative
modulation of the GABAergic system before testing can impair extinction memory expression. However, it seems possible to
speculate that inhibitory mechanisms may be required in order to acquire a memory that is inhibitory in nature. Using a combination
of behavioral protocols, such as weak and robust extinction training procedures, and pharmacological treatments, such as
the systemic administration of GABAA agonist (muscimol) and antagonist (bicuculline), we investigated the role of the GABAergic
system in the different phases of the extinction memory in the crab Neohelice granulata. We show that the stimulation of the
GABAergic system impairs and its inactivation facilitates the extinction memory consolidation. Moreover, fine variations in the
GABAergic tone affect its expression at testing. Finally, an active GABAergic system is necessary for the acquisition of the extinction
memory. This detailed description may contribute to the understanding of the role of the GABAergic system in diverse
aspects of the extinction memory.
GABAergic system impairs and its inactivation facilitates the extinction memory consolidation. Moreover, fine variations in the
GABAergic tone affect its expression at testing. Finally, an active GABAergic system is necessary for the acquisition of the extinction
memory. This detailed description may contribute to the understanding of the role of the GABAergic system in diverse
aspects of the extinction memory.
system in the different phases of the extinction memory in the crab Neohelice granulata. We show that the stimulation of the
GABAergic system impairs and its inactivation facilitates the extinction memory consolidation. Moreover, fine variations in the
GABAergic tone affect its expression at testing. Finally, an active GABAergic system is necessary for the acquisition of the extinction
memory. This detailed description may contribute to the understanding of the role of the GABAergic system in diverse
aspects of the extinction memory.
GABAergic system impairs and its inactivation facilitates the extinction memory consolidation. Moreover, fine variations in the
GABAergic tone affect its expression at testing. Finally, an active GABAergic system is necessary for the acquisition of the extinction
memory. This detailed description may contribute to the understanding of the role of the GABAergic system in diverse
aspects of the extinction memory.
c-aminobutyric acid system (GABAergic system)
during extinction memory consolidation should be similar to that described for the original trace. It is also accepted that negative
modulation of the GABAergic system before testing can impair extinction memory expression. However, it seems possible to
speculate that inhibitory mechanisms may be required in order to acquire a memory that is inhibitory in nature. Using a combination
of behavioral protocols, such as weak and robust extinction training procedures, and pharmacological treatments, such as
the systemic administration of GABAA agonist (muscimol) and antagonist (bicuculline), we investigated the role of the GABAergic
system in the different phases of the extinction memory in the crab Neohelice granulata. We show that the stimulation of the
GABAergic system impairs and its inactivation facilitates the extinction memory consolidation. Moreover, fine variations in the
GABAergic tone affect its expression at testing. Finally, an active GABAergic system is necessary for the acquisition of the extinction
memory. This detailed description may contribute to the understanding of the role of the GABAergic system in diverse
aspects of the extinction memory.
GABAergic system impairs and its inactivation facilitates the extinction memory consolidation. Moreover, fine variations in the
GABAergic tone affect its expression at testing. Finally, an active GABAergic system is necessary for the acquisition of the extinction
memory. This detailed description may contribute to the understanding of the role of the GABAergic system in diverse
aspects of the extinction memory.
system in the different phases of the extinction memory in the crab Neohelice granulata. We show that the stimulation of the
GABAergic system impairs and its inactivation facilitates the extinction memory consolidation. Moreover, fine variations in the
GABAergic tone affect its expression at testing. Finally, an active GABAergic system is necessary for the acquisition of the extinction
memory. This detailed description may contribute to the understanding of the role of the GABAergic system in diverse
aspects of the extinction memory.
GABAergic system impairs and its inactivation facilitates the extinction memory consolidation. Moreover, fine variations in the
GABAergic tone affect its expression at testing. Finally, an active GABAergic system is necessary for the acquisition of the extinction
memory. This detailed description may contribute to the understanding of the role of the GABAergic system in diverse
aspects of the extinction memory.
A agonist (muscimol) and antagonist (bicuculline), we investigated the role of the GABAergic
system in the different phases of the extinction memory in the crab Neohelice granulata. We show that the stimulation of the
GABAergic system impairs and its inactivation facilitates the extinction memory consolidation. Moreover, fine variations in the
GABAergic tone affect its expression at testing. Finally, an active GABAergic system is necessary for the acquisition of the extinction
memory. This detailed description may contribute to the understanding of the role of the GABAergic system in diverse
aspects of the extinction memory.
GABAergic system impairs and its inactivation facilitates the extinction memory consolidation. Moreover, fine variations in the
GABAergic tone affect its expression at testing. Finally, an active GABAergic system is necessary for the acquisition of the extinction
memory. This detailed description may contribute to the understanding of the role of the GABAergic system in diverse
aspects of the extinction memory.
Neohelice granulata. We show that the stimulation of the
GABAergic system impairs and its inactivation facilitates the extinction memory consolidation. Moreover, fine variations in the
GABAergic tone affect its expression at testing. Finally, an active GABAergic system is necessary for the acquisition of the extinction
memory. This detailed description may contribute to the understanding of the role of the GABAergic system in diverse
aspects of the extinction memory.