IFEC   20925
INSTITUTO DE FARMACOLOGIA EXPERIMENTAL DE CORDOBA
Unidad Ejecutora - UE
artículos
Título:
Editorial: Targeting Neuroinflammation in Central Nervous System Disorders: Uncovering Mechanisms, Pharmacological Targets, and Neuropharmaceutical Developments
Autor/es:
SARAVIA F; PÉREZ, MARIELA F.; BREGONZIO C; CASTRO M
Revista:
Frontiers In Pharmacology
Editorial:
Frontiers
Referencias:
Lugar: Lausanne; Año: 2021
ISSN:
1663-9812
Resumen:
In this special issue we present a series of reviews and research papers written from leading authorshighlighting neuroinflammation as a common target to overcome and understand brain disorders.Neuroinflammation plays a key role in Parkinson, Alzheimer, schizophrenia, major depression anddrug addiction, among others. Some threads include: autophagic dysfunction (essential for theremoval of unnecessary cellular constituents and dysfunctional components), dysfunctional centralnervous system (CNS) lymphatic drainage (dampened cleansing of molecules prone to aggregationand reduced immune cell egress into the draining cervical lymphatic nodes), traumatic brain injuryand psychostimulants and alcohol abuse disorders. The growing evidence shows that attenuation ofneuroinflammation brings beneficial effects against neurodegeneration and cognitive deficitsassociated with a plethora of CNS disorders. Considering this last issue, the identification of itsmost relevant biological processes and possible pharmacological targets remains a major challenge