AngiotensinII and the hypertensive pregnancy

BIAGGIO VS,; LÓPEZ AGUILERA F; SELTZER AM

Mendoza Ciudad (Centro de Reuniones y Exposiciones)

Congreso; Reunión de la Sociedad de Biología de Cuyo 2010; 2010

Sociedad de Biologia de CuyoSecretaría de Ciencia, Técnica y Post Grado UN de Cuyo,

Hypertension during pregnancy and placental vascular insufficiency are common conditions that affect the development of the fetus. The offspring of spontaneously hypertensive (SHR) rats during uterine life suffer vascular aberrations that increase their mortality rate and delay the maturation of the nervous system. The members of the renin-angiotensin system (RAS) are present in the brain, cerebellum and placenta of pregnant females and angiotensin II and its cell membrane receptors AT1 and AT2 are known to play a role in the vascular events that occur during the adaptive response to high blood pressure. In addition we propose their participation in the remarkable spontaneous recovery of neurological and behavioral defects that show the surviving pups. Our project is aimed to the study the expression of these receptors in the placental vasculature of normotensive Wistar Kyoto (WKY) and SHR rats and in the brain and cerebellum of their offspring during development. In the present work we show anatomical and histological differences among these two groups of animals that will allow us in the future to evaluate pharmacological interventions on the RAS system.