IHEM 20887
INSTITUTO DE HISTOLOGIA Y EMBRIOLOGIA DE MENDOZA DR. MARIO H. BURGOS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
O-GlcNAcylation regulates secretory pathways during CD8 T cell dysfunction
Autor/es:
BANNOUD N; RUETE MC; KINDGARD L; RABINOVICH GA; D`ALOTTO-MORENO T; CROCI DO
Lugar:
Buenos Aires
Reunión:
Simposio; 3rd Argentinian Symposium on Glycobiology. GlycoAr 2019; 2019
Institución organizadora:
Universidad Nacional de San Martin. IBYME. IHEM. CIQUIBIC. INSTITUTO LELOIR
Resumen:
T cell exhaustion is one of the mechanisms that accounts for immunosuppression on the tumor microenvironment. It is characterized by a sustained overexpression of inhibitory receptors and a progressive loss of effector functions. The aim of this study was to investigate the biogenesis and exocytosis of cytotoxic granules during CD8 T cell exhaustion, focusing on the role of O-GlcNAcylation as regulator of these processes. To address this, we purified splenic CD8 T cells from C57/BL6 mice and exposed them to an activation/reactivation cycle using anti CD3/CD28 to generate exhausted CD8 T cells (CD8ex). CD8ex showed higher expression of PD1 and Tim-3 (p
