IHEM   20887
INSTITUTO DE HISTOLOGIA Y EMBRIOLOGIA DE MENDOZA DR. MARIO H. BURGOS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Intrinsic disorder in alpha-synuclein: effects on bending lipid bilayers
Autor/es:
DIEGO M. BUSTOS; MARCELO CAPAROTTA; DIEGO MASONE
Lugar:
Mendoza
Reunión:
Congreso; X Congreso Argentino de Bioinformática y Biología Computacional (10CA2BC); 2019
Institución organizadora:
CONICET-UNCuyo
Resumen:
Curvature-related processes are of major importance during protein-membrane interactions. The illusive simplicity of membrane reshaping masks a complex molecular process crucial for a wide range of biological functions like fusion, endo and exocytosis, cell division, cytokinesis and autophagy. In this work, we have studied alpha-synuclein interactions with a ternary lipid bilayer, inducing curvature in a controlled manner and describing protein responses in the Martini coarse-grained space. By calculating free energy profiles for bending the bilayer, we describe alpha-synuclein capabilities in sensing curvature and we highlight the importance of its intrinsically disordered region.