IHEM   20887
INSTITUTO DE HISTOLOGIA Y EMBRIOLOGIA DE MENDOZA DR. MARIO H. BURGOS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Pigment epithelium-derived factor (PEDF) expression in the reproductive tract of male rats is regulated by androgens
Autor/es:
SAEZ LANCELLOTTI T.E.; PIETOBON EO; CONTE MI; VINCENTI A.E; FORNÉS M.W; CABRILLANA M.E; LOPEZ ME; MONCLUS M.A
Lugar:
Mendoza
Reunión:
Simposio; 1st Freiburg-Mendoza Symposium on Traslational Medicine; 2018
Institución organizadora:
Freiburg University - UNCuyo
Resumen:
PIGMENT EPITHELIUM-DERIVED FACTOR (PEDF) EXPRESSION IN THE REPRODUCTIVE TRACT OF MALE RATS IS REGULATED BY ANDROGENSDr. María de los Ángeles MONCLUS. Área de Histología y Embriología de la Facultad de Ciencias Médicas de la Universidad Nacional de Cuyo. Instituto de Histología y Embriología de Mendoza (IHEM-CONICET). As an introduction, I would like to tell you that the target of our laboratory is the male reproductive system and, in my particular case, the epididymis.This organ is crucial in the maturation of spermatozoa, because when these cells leave the testicle they are not yet functionally mature.Anatomically, the epididymis is divided into four regions: initial segment, caput, corpus and cauda, which continues with vas deferens. This functional maturation is achieved as sperm progresses through the epididymal duct by interacting with the luminal microenvironment, a highly complex medium that is produced and maintained by epididymal epithelial cells. This phenomenon occurs in the proximal areas of the epididymis, while in the cauda region mature spem remain stored in a quiescent state until ejaculation.It is very important to maintain the integrity of these cells is during storage.In previous works we analyzed a phenomenon that occurs while spermatozoa of several mammalian species are stored in the epididymal cauda.This phenomenon is the sperm conjugation. Sperm are not randomly arranged in the lumen but can be associated with each other by forming conjugates of spermatozoa. Usually the association is produced by sperm heads and the flagella are free. After ejaculation, immobile sperm acquire motility and allow the movement of these conjugates in the female tract.Finally, each sperm is separated, disassembling the conjugate and we obtain a suspension of mobile spermatozoa.These conjugates have different morphology depending on the species and have been observed for example in guinea pig, American marsupials, the Australian Echidna , Wood mouse among other examples.In our laboratory, we describe and characterize this phenomenon in rat and laboratory mouse and call them rosettes.