IHEM   20887
INSTITUTO DE HISTOLOGIA Y EMBRIOLOGIA DE MENDOZA DR. MARIO H. BURGOS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Alphasynuclein and membrane curvature
Autor/es:
DIEGO MASONE
Lugar:
Mendoza
Reunión:
Seminario; Seminario Interno - Instituto de Histología y Embriología de Mendoza (IHEM); 2019
Institución organizadora:
Instituto de Histología y Embriología de Mendoza (IHEM)
Resumen:
Currently, membrane curvature is understood as an active mechanism to control cells spatial organization and activity. Therefore, protein processes involved in sensing and generating curvature are of great interest. In this work, we have studied alpha-synuclein interactions with a model lipid bilayer. We have induced curvature in a controlled manner and we have described protein responses at molecular level using the Martini coarse-grained model. We show that the intrinsically disordered region of alpha-synuclein binds to the bilayer only as an acknowledgment to the induced curvature. We demonstrate that alpha-synuclein deflects from disorder to order as the bilayer bends and that the disordered region is a key element for sensing curvature.