Action of natural products in an experimental model of allergic inflammation of upper and lower airways

PENISSI AB; MARIANI ML; MANCINO MOREIRA G; ALVARADO M; CARDOZO M

Buenos Aires

Congreso; Reunión Conjunta de Sociedades de Biociencias 2017; 2017

Introduction: Allergic inflammation is a pathophysiological feature of numerous medically important processes including allergic asthma. These types of conditions deteriorate the quality of life of those affected and so far there are no effective treatments. In previous work we have shown that dehydroleucodine (DhL), active ingredient of Artemisia douglasiana Besser (regional medicinal plant popularly known as "matico") exhibits antiulcerous, anti-inflammatory and antioxidant activity.Objective: To determine the action of the lyophilized extract (LE) of matico in the prevention / treatment of allergic and inflammatory pathologies.Materials and methods:Adult male rats, Wistar strain. Group (G) ref: without any treatment. Control G (-): received intraperitoneal injection and nebulization with PBS. Control G (+): sensitized with an intraperitoneal injection of birch pollen and nebulized with the same substance. LEG (A): nebulization with a low concentration of LE. GLE(B): nebulization with a higher concentration of LE. BuG: nebulized with Budesonide (anti-inflammatory of the airways). Nebulizations were performed 25 days after sensitization. After the treatment, peripheral blood was removed and the leukocyte formula was analyzed. Statistics analysis: ANOVA-1 followed by Tukey-Kramer test.Results:Segmented neutrophils: increased in LEG (A) compared to CG (-) P