IHEM   20887
INSTITUTO DE HISTOLOGIA Y EMBRIOLOGIA DE MENDOZA DR. MARIO H. BURGOS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
GLUTAMIC ACID: LOCATION AND FUNCTIONAL STUDIES ....
Autor/es:
SORIA M; GIULIANI F; CABRERA R; FORNES M W
Lugar:
Ciudad de La Punta, SL
Reunión:
Congreso; Reunión Anual Soc. Biol. Cuyo; 2009
Institución organizadora:
Soc. Biol. Cuyo
Resumen:
159.
GLUTAMIC ACID: LOCATION AND FUNCTIONAL STUDIES
IN SPERM, SPERMATOGENESIS AND FALLOPIAN
TUBE IN MOUSE
Soria MG, Giuliani FA, Cabrera RJ, Fornés MW.
IHEM - Facultad de Ciencias Médicas - UNCuyo. Mendoza. Email:
msoria@fcm.uncu.edu.ar
The Glutamic Acid (Glu) is well studied at the central nervous system
(CNS), although Glu receptors (GluRc) and Glu functions have
not been fully described in sperms or fallopian tubes (FT). We reported
the presence of GluRc in sperm cell and Glu as a triggering
molecule of acrosomal reaction (AR). Now GluRc location was
also extending to FT and mouses testis. The GluRc was detected
during the spermatogenesis in specific stadium related to acrosomal
development. On the other hand, the same antibodies imuno
stained the epithelium of FT according to sexual cycle. Again
superfussion assays (SA) to establish the release uptake of Glu
was definitive demonstrated at the CNS, but not at the FT. In FT is
important because is the physiological place for induction of AR.
Recently, SA in the FT was positive. Moreover, these interchange
had also a relationship with the stadium of the female sexual cycle.
The uptake and release was different within the female cycle showing
high uptake during diestrus and releasing at the estrus. Results
indicate that sperm possesses GluRc progressively expressed
during spermatogenesis -, Glu promote AR and Glu is secreted and
capture by FT - following the sexual cycle to promote high level
of Glu at the fertilization place and moment.