IHEM   20887
INSTITUTO DE HISTOLOGIA Y EMBRIOLOGIA DE MENDOZA DR. MARIO H. BURGOS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
α1,2-AP2 EXPRESSION IN THE DEVELOPING BRAIN OF SPONTANEOUSLY HYPERTENSIVE RAT
Autor/es:
ASENSIO J; TRONCOSO M; SOSA M; SELTZER A
Lugar:
Mar del Plata
Reunión:
Congreso; XXXII CONGRESO ANUAL SAN (Sociedad Argentina de Neurociencias); 2017
Institución organizadora:
Sociedad Argentina de Neurociencias
Resumen:
Clathrin coated vesicles (CCV) internalize different cargo proteins and CCV participate in the retrieval of empty synaptic vesicles, which is important for recycling the membrane components. The dynamic formation of cell?cell interactions during nervous system development depends on CCV. They consist of a clathrin triskelia and adaptor protein complexes (Mitsunari et al., 2005). α-AP2 subunit has two isoforms: α1-AP2 (highly concentrated in nerve terminals) and α2-AP2 (cytoplasmic distribution in the cell body and dendrites) (Ball et. al 1995). There is evidence that AP2 binding to the plasma membrane is altered in neurodegenerative diseases and also in the developing brain that suffers a hypoxic/ischemic insult. The distribution in brain areas of these isoforms and their respective expression levels have not been elucidated yet. The Spontaneously Hypertensive Rat (SHR) has been proposed as a model to study intrauterine growth restriction (IUGR), since placental blood flow is reduced and the fetus develops under hypoxic conditions. In previous work, we found that SHR pups present impaired neurological development and alterations in the arrangement of the granular cell layer of cerebellar cortex.