IHEM 20887
INSTITUTO DE HISTOLOGIA Y EMBRIOLOGIA DE MENDOZA DR. MARIO H. BURGOS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Carvedilol (Crv) Inhibits the Trypanosoma cruzi Autophagic Pathway Affecting Parasite Replication and Survival
Autor/es:
CUETO JA; VANRELL C; RIVERO CYNTHIA V; ROMANO PS
Lugar:
New Orleans
Reunión:
Congreso; IDWEEK 2016; 2016
Institución organizadora:
IDweek group
Resumen:
Chagas disease is caused by the protozoan T. cruzi. Pathogenesis of Chagas heart disease (CHD) involves low-grade incessant systemic infection and triggered an autoimmune reaction. Cruzipain (CZP) is a key virulence factor of T. cruzi. Autophagy is an intracellular (IC) pathway that affects survival and/or virulence of parasites. A recent study showed that Crv was effective in reducing oxidative damage in CHD.
