Effect of hypercholesterolemia in prostate of adult male rabbits. Reversal of adverse effects by olive oil added to fat diet

SIMON LAYLA; FUNES A.K.; MONCLUS MA; CABRILLANA M.E; COLOMBO R; SAEZ LANCELLOTTI T.E.; FORNÉS M.W

Mendoza

Otro; XXXIV Reunión Científica Anual de la Sociedad de Biología de Cuyo; 2016

Sociedad de Biología de Cuyo

Hypercholesterolemia (HC) is a biochemist and serum marker of chronic non-communicable diseases in adults, mostly linked to excessive fat intake. In recent years, it is also associated with male infertility. In male rabbits fed with fat diet (FD), it was detected a decrease in seminal volume (Control 759.8 μl ± 68.66; FD: 432.2 μl ± 45.6), a reduction in sperm count and an increase in sperm morphological abnormalities. Semen volume is produced by the secretion of the accessory glands coupled to male tract, as prostate. Therefore, the decrease in seminal volume could be explained by alterations in one or all of them. Mediterranean diet is a healthy diet indicated for HC treatment. Its main fat component is olive oil (OO). The addition of OO to the diet could reverse the glandular disorders. Prostate samples of animals under balanced rabbit diet (control), FD or protective diet by addition of OO (Protective diet, PD) were obtained. They were processed for light microscopy and morphometry was performed using Image J program. Histology showed a decrease in villi area in FD and an increase in PD in comparison to control prostates (Control: 99621 ± 19727 μm2; FD: 49272 ± 5228 μm2; PD: 131808 ± 17931 μm2, p