Galectin-1 contributes to the pro-angiogenic activity of myeloid-derived cells

CROCI DO; ILARREGUI JM; BLIDNER, AG; RABINOVICH GA.

GUANAJUATO

Congreso; CONGRESO LATINOAMERICANO DE GLICOBIOLOGIA; 2015

LASID

Myeloid cells are essential for the normal function of the immune system to protect against pathogens and injuries, although they have also gained particular relevance because of their dual roles of creating pro-inflammatory or immunosuppressive networks at sites of tumor growth and metastasis. The aim of this study was to investigate the contribution of galectin-1 (Gal1) to the proangiogenc activity of tumor-associated myeloid cells. We first induced tolerogenic dendritic cells (tDCs) from wild type (tDC-WT) or Lgals1-/--C57BL/6 mice (tDC-KO) using Gal1 or VtiD3 and evaluated their proangiogenic activities. In vivo inoculation of DCs in Matrigel plugs in C57BL/6 mice revealed the ability of tDCs to induce angiogenesis compared to LPS-differentiated immunogenic DCs (p