DEHYDROLEUCODINE DELAYS MELANOMAS GROWTH GENERATED IN MICE OF STRAIN C57/BL6.

COSTANTINO VV, AMAYA MC, LÓPEZ LA

Mendoza

Congreso; XXXI Reunión Científica Anual de la Sociedad de Biología de Cuyo; 2013

Cancer is characterized by an abnormal cells proliferation with ability to invade organs and tissues. Among antitumor drugs currently studied, the sesquiterpene lactones (SLs) are particular interest due to its antiproliferat ive activity. Dehydroleucodine (DhL) is a SL purified from Artemisia douglasiana Besser, a plant of Argentine west center. Previous results from our laboratory showed that DhL induces genotoxic damage and inhibits the tumor cells proliferation, arresting them in the G1 and G2/M cell cycle phase. Furthermore, according to the used concentration; DhL induces senescence or apoptosis. Based on the above, in this work we proposed to determine the DhL action in melanoma growth generated in mice C57/BL6. For this, mice with implanted melanoma were subjected to three treatments with 23 mg/kg DhL: 1) the administration started 15 days before tumor implantation, 2) the administration began the same day of implantation and 3) the administration began when the volume the tumor reached a volume of 200 mm3. In every case, the treatment ended when the tumor volume reached 2500mm3. DhL produced a decrease in tumor volume of 64, 61.3 and 47.3% respectively in the three administration protocols evaluated. These results indicate that DhL delays melanomas growth generated in an animal model, showing a potent antitumor effect.