WT1 methylation: an epigenetic marker in breast cancer?

LAURITO SERGIO; CAMPOY, EMANUEL; BRANHAM MARIA TERESITA; URRUTIA GUILLERMO; GAGO FRANCISCO; TELLO OLGA; ROQUÉ MARIA

Sitges

Congreso; Cell Symposia: Cancer epigenomics; 2013

Epigenetics is postulated to be the bridge between environment and phenotype. The aberrant methylation associated with tumorigenic processes could therefore present distinct profiles among different populations. Our analysis on 95 breast tumors of our country reveal that 92.6% present methylation of a CpG island located in the promoter region of WT1 gene and of antisense AS-WT1 gene. This prevalent frequency has not been informed by others in breast tumors of other populations. Compared with normal breast tissue, this alteration is strongly associated with the tumor (p