CHOLESTEROL-LOWERING AND ANTIOXIDANT EFFECTS OF THE PLANTAGO MAJOR IN RABBITS

ABUD MA; FORNÉS MW ; PONCE C; CEJUDO C; TORTI J; GARCIA M; SIMÓN LAYLA; SAAD JR; MARÍA AO

Congreso; XXXI Reunión científica anual de la SBCuyo; 2013

The purpose of this study was to demonstrate the hypocholesterolemic and antioxidant effect of a 2% plantain infusion in rabbits treated with a lipid diet. White New Zealander male rabbits were used and randomized into 3 experimental groups. Lot 1 Control: balanced food (AB). Lot 2. Hypercholesterolemic (HC): AB supplemented with lipids. Lot 3. Experimental (HC + 2% plantain infusion in drinking water for 3 months). At the beginning and end of treatment, blood was extracted from the ear of the animal for biochemical determinations. Baseline values: Lot 1: Col (Total cholesterol, mg/dL): 78 ± 1.54, Trig.(Triacylglycerides, mg/dL) 55 ± 1.06, HDL( mg/dL) : 18 ± 1.45. Lot 2: Col. 136 ± 2.01, Trig: 73 ± 1.65, HDL. 10 ± 0.85. Lot 3: Col. 127 ± 1.94,Trig. 68 ± 0,58, HDL: 14 ± 1.73. Post treatment (90 days): Lot 1: Col: 74 ± 0,94 , Trig: 57 ± 1.62, HDL: 19 ± 0.88. Lot 2: Col: 128 ± 1.33, Trig: 68 ± 0,95 ; HDL: 9 ± 0,19. Lot 3: Col: 54 ± 1,31, Trig: 61 ± 1,06, HDL: 16 ± 0.38. Malonildialdehyde, total antioxidant activity and gutathione peroxidase were determined as oxidative stress parameters. In this study, rabbits fed with a lipid diet that drank the 2% plantain infusion showed a significant decrease in cholesterol levels and a protective effect on lipid peroxidation.