IHEM   20887
INSTITUTO DE HISTOLOGIA Y EMBRIOLOGIA DE MENDOZA DR. MARIO H. BURGOS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Castration induces changes in expression and distribution of receptors in rat epididymis. Implications on Cathepsin D secretion
Lugar:
Aguas de San Pedro- San Pablo
Reunión:
Congreso; Fifth International Conference on the Epididymis; 2010
Resumen:
It is
well known that the epididymal epithelium (which is stimulated by steroid
hormones) is involved in the process of sperm maturation through its secretory
activity. High concentrations of some acid hydrolases have been found in the
epididymal lumen, an intriguing fact considering that these enzymes should be
confined to an intracellular compartment. Moreover, it was confirmed that some enzymes are secreted into the
epididymal lumen in response to androgenic hormones. In other cells and
tissues, acid hydrolases are selectively transported to lysosomes via mannose -6-phosphate
receptor (MPRs), although alternative routes of transport have been described.