Protein Kinase C: Function in Intracellular Trafficking, in Health and Disease

CAPMANY A; DAMIANI MT

Advances in Medicine and Biology.

NOVA SCIENCE PUBLISHERS, INC.

Lugar: Nueva York; Año: 2012; p. 1 - 18

This chapter introduces data revealing a strong link between PKC activation and the regulation of intracellular trafficking and the fate of many receptors. It will also provide a brief overview of the most significant publications in the field. The recognition of PKC impact in the control of intracellular trafficking will increase the understanding of physiological processes, such as down regulation of the number of receptors exposed at the cell surface by either intracellular trapping or lysosomal degradation. This knowledge may lead to the design of new therapeutic tools for the treatment of pathologies in which a PKC-regulated transport step is altered, most notably Alzheimer?s disease, Niemann-Pick type C 1 disease, Duchenne muscular dystrophy and diabetes