Role of VAMP7-Dependent Secretion of Reticulon 3 in Neurite Growth

NOLA, SÉBASTIEN; FILIPPINI, FRANCESCA; MAN LAM, SIN; OUSLIMANI, AMINE; COLOMBO, MARIA ISABEL; WOJNACKI, JOSÉ; CHOLLEY, BÉATRICE; LIPECKA, JOANNA; SIMON, AXELLE; FADER, CLAUDIO MARCELO; GALLI, THIERRY; BUN, PHILIPPE; PRESSÉ, MARY T.; N'GUYEN, JULIE; SHUI, GUANGHOU; GUERRERA, IDA CHIARA

Cell Reports

Elsevier B.V.

Año: 2020 vol. 33

VAMP7 is involved in exocytosis-mediated neurite growth and degradative autophagy. Using secretomics, Wojnacki et al. show that VAMP7 mediates the release of tubular ER-phagy receptor Reticulon 3, a secretory pathway greatly enhanced in autophagy-null neuronal cells. ER-phagy and unconventional secretion regulate neurite growth and polarization during nutrient deprivation.